SPICE III Study Recruitment Completed

This afternoon, around 2.30pm Melbourne time, SPICE III Study reached its recruitment target of 4000 patients across 67 sites.

The primary aim of this study is to determine whether Early Goal-Directed Sedation, compared to standard care sedation, reduces 90-day mortality in critically ill patients who are expected to require mechanical ventilation for longer than 24 hours.

Congratulations to Chief Investigator, Professor Yahya Shehabi, on the successful completion of recruitment. His passion and enthusiasm for research is infectious and we look forward to reading the results of the trial.

Project Manager Belinda Howe has been a pleasure to work with over the past ten years both for SPICE III and ARISE. Her pragmatism and commitment to monitoring has positively influenced data quality and kept the trial running smoothly.

The first patient was recruited in November 2014, only a few months after ARISE study completed recruitment.

Well done to ANZIC-CTG and the staff across all 67 sites who have worked hard over the past three and a half years on the research, in addition to their work caring for these critically ill patients. The outcome of this research will help improve patient outcomes in the future.

The team at Research Path are very proud to be been involved in the trial. Although this is end of recruitment there are still important milestones to come, with which we will continue supporting the trial team.

If you would like to know more about the trial or get in touch with the team visit https://www.spicestudy.org/.

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